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After learning that Mania had had her symbiote stolen, Flash assumed the culprit was the one responsible for separating him from the Venom symbiote. Using the traces of the Venom symbiote inside his body as a compass, Flash tracked it to Alchemax Tower, where he discovered it had re-bonded to Eddie Brock. Flash confronted Brock and attempted to have the symbiote return to him. While the symbiote was struggling to decide which host to go to, and latched to both men at the same time, Spider-Man appeared on the scene. He overturned a vat of artificial Anti-Venom serum developed by Alchemax on Flash and Eddie in an attempt to kill the symbiote. Instead of killing the symbiote, the serum turned the portion of it bonded with Flash into a new Anti-Venom, which transformed Flash into a color-inverted version of his Agent Venom form. Flash was able to use the Anti-Venom symbiote to completely remove the Venom symbiote from Eddie, but couldn't bond with it himself. Leaving the symbiote at Bobbi Morse's apartment for safekeeping, Anti-Venom and Spider-Man set out to track down the Mania symbiote and traced it to Black Cat's hideout, where they discovered Felicia's gang had been infected with the symbiote by its new host, Maniac.